PE-22-28 overview:
Type: Synthetic neuropeptide fragment derived from BDNF (Brain-Derived Neurotrophic Factor).
Sequence: Ala-Ile-Tyr-Lys-Glu-Asn-Ala
Molecular weight: ~836.9 Da
Chemical class: Short peptide analog of the active domain of BDNF.
Mechanism of Action:
PE-22-28 mimics key biological actions of BDNF by activating TrkB (tropomyosin receptor kinase B) receptors—central mediators of neuronal growth, differentiation, and synaptic plasticity.
Promotes neurite outgrowth and synaptic repair in neuronal cell cultures.
Enhances neuronal survival and communication under oxidative or excitotoxic stress.
Does not significantly increase oxidative stress or toxicity, unlike some full-length BDNF mimetics, making it valuable in neuroprotection research.
Pharmacological / Research Insights:
Neuroprotective. Supports neuron survival, synaptic function, and mitochondrial stability.
Antidepressant-like effects: Shown in preclinical models to improve mood-related behaviors via serotonergic and dopaminergic modulation.
Cognitive enhancement: Associated with improved learning and memory in animal studies, likely through TrkB activation and CREB signaling.
Synergy potential: When combined with neuroactive or mitochondrial peptides (e.g., Pinealon, Epitalon, Semax), may enhance neuroplasticity, resilience, and cognitive repair pathways.
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This peptide is for research purposes ONLY. It is not approved for human consumption or medical use.
All handling and usage must comply with applicable regulations and guidelines for laboratory research.
By purchasing this product you agree to the condition of its handling by qualified laboratory professionals only.
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Additional information:
The product (substance) isn’t a food or diet supplement.
Keep out of children’s reach.
Keep container tightly closed.
Store below 8 °C; protect from moisture.
Store only in the original container.
Avoid contact during pregnancy and breastfeeding.
Consult a doctor in the event of feeling unwell or having adverse effects related to contact with the substance.