GLP-3 overview.
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This peptide is a novel investigational compound that functions as a triple agonist, targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon. It is being researched for its potential effects on weight loss and metabolic regulation.
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Mechanism of Action:
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The peptide exerts its effects by simultaneously activating three key receptors involved in glucose and energy homeostasis:
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1. GLP-1 Receptor Agonism: Activation of the GLP-1 receptor enhances insulin secretion from pancreatic beta cells in a glucose-dependent manner, delays gastric emptying, and reduces appetite through central mechanisms in the hypothalamus. It also decreases glucagon secretion from pancreatic alpha cells, contributing to improved glycemic control.
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2. GIP Receptor Agonism: By stimulating the GIP receptor, the peptide enhances insulin release in response to nutrient intake and promotes beta-cell proliferation and survival. GIP receptor activation has also been linked to improved adipocyte function and reduced fat accumulation.
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3. Glucagon Receptor Agonism: Activation of the glucagon receptor increases energy expenditure by enhancing hepatic glucose production and lipid metabolism. It also promotes fat oxidation and reduces body fat mass, contributing to overall weight loss.
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The combined activation of these three receptors creates a synergistic effect that leads to significant reductions in body weight, improved insulin sensitivity, enhanced glycemic control, and reduced appetite.
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Molecular Sequence and Weight:
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The peptide is a synthetic analog with a modified amino acid sequence to optimize receptor binding and biological stability. Its molecular sequence is engineered to mimic the natural hormone structures of GLP-1, GIP, and glucagon, with specific modifications to improve half-life and resistance to enzymatic degradation. The molecular weight of the peptide is approximately 5,100 to 5,500 Daltons (depending on the specific formulation and modifications).
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Research and Applications:
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The peptide is currently under investigation for its potential therapeutic benefits in obesity, type 2 diabetes, and metabolic syndrome. Preclinical and clinical research have demonstrated significant reductions in body weight and improvements in glucose metabolism with this compound.
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This peptide is for research purposes ONLY. It is not approved for human consumption or medical use. All handling and usage must comply with applicable regulations and guidelines for laboratory research. By purchasing this product you agree to the condition of its handling by qualified laboratory professionals only.
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Additional information:
*The product (substance) isn't a food or diet supplement.
*Keep out of children's reach
*Keep container tightly closed.
*Store below 8°C; protect from moisture.
*Store only in the original container.
*Avoid contact during pregnancy and breast feeding.
*Consult a doctor in the event of feeling unwell or having adverse effects related to the contact with the substance.