GLP1 overview
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This compound is a glucagon-like peptide-1 (GLP-1) receptor agonist designed to mimic the natural hormone involved in glucose metabolism and appetite regulation. It is a synthetic analog of human GLP-1, with modifications that enhance its stability and prolong its half-life in the body. Its molecular structure consists of 31 amino acids. The compound is modified by the attachment of a fatty acid chain, which allows it to bind to albumin in the bloodstream, thereby extending its duration of action.
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Mechanism of Action
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The compound acts by binding to and activating the GLP-1 receptor (GLP-1R) on pancreatic beta cells. This activation enhances glucose-dependent insulin secretion while simultaneously inhibiting glucagon release, leading to improved glycemic control. Additionally, it slows gastric emptying and increases satiety by acting on the central nervous system, particularly the hypothalamus, which regulates appetite. This dual effect on glucose metabolism and appetite suppression contributes to significant reductions in body weight over time.
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Upon subcutaneous administration, the compound’s prolonged half-life allows for once-weekly dosing. Its resistance to degradation by dipeptidyl peptidase-4 (DPP-4) is conferred by the fatty acid side chain modification, which also facilitates albumin binding and reduces renal clearance.
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Molecular Composition
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Amino acid sequence: 31 amino acids, modified from the native GLP-1 sequence
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Molecular weight: Approximately 4113.64 Da
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Chemical modification: Fatty acid chain attachment for albumin binding and extended half-life
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This peptide is for research purposes ONLY. It is not approved for human consumption or medical use. All handling and usage must comply with applicable regulations and guidelines for laboratory research. By purchasing this product you agree to the condition of its handling by qualified laboratory professionals only.
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Additional information:
*The product (substance) isn't a food or diet supplement.
*Keep out of children's reach
*Keep container tightly closed.
*Store below 8°C; protect from moisture.
*Store only in the original container.
*Avoid contact during pregnancy and breast feeding.
*Consult a doctor in the event of feeling unwell or having adverse effects related to the contact with the substance.