TB-500 overview:
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Introduction:
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TB-500 is a synthetic version of a naturally occurring peptide known as Thymosin Beta-4 (Tβ4). Thymosin Beta-4 is a 43-amino acid peptide that is produced in the thymus and is found in high concentrations in blood platelets, wound fluid, and other tissues. TB-500 is specifically designed to replicate the effects of Thymosin Beta-4, primarily to promote healing, reduce inflammation, and support tissue regeneration. It has gained significant attention in the field of regenerative medicine and sports science due to its potential to accelerate recovery from injuries and enhance muscle and tissue repair.
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Molecular Structure and Sequence:
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Molecular Formula: C212H350N56O78S
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Molecular Weight: Approximately 4963.44 g/mol
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Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Ala-Glu-Gln-Cys-Pro-Leu-Ser-Ser-Thr-Cys-Glu-Ser-Thr-Gln-Glu-Lys-Asn-Gly-Ala-Ser-Thr-Ala-Ser-Gly-Tyr-Ala-Gly-Glu-Phe-Thr-Glu-Lys
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TB-500 is a short synthetic peptide fragment of Thymosin Beta-4, consisting of a sequence that includes the active region responsible for the biological activity of Tβ4.
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Mechanism of Action:
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TB-500’s mechanism of action is closely related to the biological functions of Thymosin Beta-4. It primarily works by regulating the cellular components involved in the healing and repair processes:
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1. Actin Regulation and Cell Migration:
TB-500 has a high affinity for actin, a protein that forms the cytoskeleton of cells and is crucial for cell shape and motility.
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TB-500 binds to actin monomers and promotes the polymerization of actin into filaments, enhancing the formation of the cytoskeleton and facilitating cell movement.
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This increased cellular motility allows for more efficient migration of repair cells (such as fibroblasts and endothelial cells) to the site of injury.
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2. Angiogenesis (Formation of New Blood Vessels):
TB-500 promotes the expression of vascular endothelial growth factor (VEGF), which is a key signal protein involved in angiogenesis.
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Increased VEGF levels result in the formation of new blood vessels, improving blood supply to damaged tissues and enhancing nutrient delivery for tissue repair.
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3. Anti-Inflammatory Effects
TB-500 reduces levels of pro-inflammatory cytokines (e.g., IL-1, IL-6) and increases levels of anti-inflammatory cytokines (e.g., IL-10).
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This leads to reduced swelling and pain at the injury site, creating a more favorable environment for tissue regeneration.
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4. Collagen and Tissue Remodeling
TB-500 increases the production of type I and type III collagen, which are essential components of connective tissue (tendons, ligaments, skin).
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This enhances the structural integrity and strength of newly formed tissue.
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5. Protection Against Apoptosis (Cell Death):
TB-500 has been shown to prevent apoptosis in injured cells by upregulating cell survival pathways.
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This allows more cells to survive and participate in the repair process.
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6. Hair Growth and Skin Healing:
TB-500 has been linked to enhanced hair follicle stem cell activity, leading to improved hair growth and regeneration of skin cells.
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Potential Applications (Research-Based):
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While TB-500 is not approved for human use, research studies have explored its potential benefits in the following areas:
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Muscle and tendon injuries – Accelerates recovery from muscle strains and tendonitis.
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Wound healing – Promotes faster healing of cuts, burns, and surgical wounds.
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Joint health – Improves flexibility and reduces joint pain through increased collagen production.
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Cardiac health – Potential to support healing of heart tissue following myocardial infarction (heart attack).
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Neurological protection – May have neuroprotective effects through its anti-inflammatory and cell survival properties.
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Hair and skin regeneration – Encourages skin renewal and hair follicle growth.
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Side Effects and Safety Profile
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Research studies have reported the following potential side effects:
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Mild redness or irritation at the injection site.
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Temporary fatigue or lethargy following administration.
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Possible headaches or dizziness.
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TB-500 has shown a favorable safety profile in research settings, with no major adverse effects reported when used within established research protocols.
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TB-500 is classified as a research chemical and is not approved by the FDA or other regulatory bodies for human consumption or therapeutic use. It is intended for use in laboratory research and scientific studies only. Any use outside of a controlled research environment is prohibited and may carry legal and health risks.
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**NOT FOR HUMAN CONSUMPTION. **FOR RESEARCH PURPOSES ONLY.